Title: The effect of PUVA therapy on concentrations of IgG subclasses in the sera of patients with psoriasis
- Ryszard Żaba, Jacek Losy
- Original articles
- Clinical Dermatology
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- Final page:
- psoriasis vulgaris, IgG subclasses, PUVA therapy
Backround: Markers of disease activity in patients with psoriasis are necessary to monitor therapy. A variety of immunological markers have been reported to be elevated in patients with psoriasis treated by PUVA.Objective: The aim of this study was to determine the effect of PUVA therapy in patients with psoriasis on levels of IgG subclasses in sera.Material and methods: Levels of IgG subclasses in sera of 14 patients with psoriasis vulgaris treated with PUVA were determined. Results: In the present study, significantly higher levels of IgG1 were observed in patients with psoriasis vulgaris. An increase in the concentration of IgG1 during PUVA therapy in patients with psoriasis was not significant. There was also no meaningful difference in the concentration of IgG2, IgG3 and IgG4 between the study and control groups. There was no statistical correlation between serum concentration of IgG subclasses and the PASI score.Conclusions: 1) The studies showed a significant increase of IgG1 in patients with psoriasis in comparison to control group. 2) PUVA therapy does not influence serum concentrations of IgG subclasses in patients with psoriasis vulgaris.