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Articles

Title: Current views on the role of apoptosis in chronic pancreatitis

Author:
Agnieszka Mądro, Krzysztof Celiński, Maria Słomka
Type:
Review articles
Language:
PL
Journal:
Polish Gastroenterology
Year:
2003
Volume:
10
Number:
5
Start page:
449
Final page:
452
ISSN:
1232-9886
Keywords:
chronic pancreatitis, apoptosis, markers of apoptosis
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Chronic pancreatitis is the disease whose pathomechanism, despite new discovered relations, is still unk-nown. Some advances have been made due to detection and description of the pancreatic stellate cells. Moreover, numerous reports concerning the role of apoptosis in chronic pancreatitis are being published. The studies are focused on the importance of this phenomenon in relation to the lobular cells of the gland, pancreatic stellate cells, expression of genes and searching for new markers of apoptosis. The first published experimental studies evaluated the effects of pro- and antiapoptotic factors particularly on the lobular and pancreatic stellate cells. It was demonstrated that cell proliferation in chronic pancreatitis, although in-creased compared to that in the normal pancreas, did notpreventthelossofexocrine gland function. These findings confirm the clinical observations that in chronic pancreatitis the endocrine function is best protec-ted and becomes impaired only in the late stage of the disease. The above mentioned observations contri-bute to progress in the treatment of chronic pancreatitis.