Title: Phytic acid as a potential anti-cancer agent against the colon tumors
- Ludmiła Węglarz, Beata Parfiniewicz, Zofia Dzierżewicz, Tadeusz Wilczok
- Review articles
- Polish Gastroenterology
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- Final page:
- phytic acid, colonocytes, colon cancer
Phytic acid (inositol hexaphosphate) is a naturally existing compound that has various biological activities. One of the most mysterious but potentially important activities is its reported antineoplastic action. Both in vivo and in vitro experiments have suggested striking anticancer potential (preventive as well as therapeu-tic) for phytic acid in the colon carcinogenesis. In addition to reducing malignant colonocyte proliferation, it affects crypt morphology, rate of apoptosis and degree of differentiation of tumor cells. Because the con-centration of phytic acid is high in high-fiber diets, these diets have been credited with reducing the risk of the colon cancer. This review presents the up-to-date facts pointing to the protective effects of phytic acid against the colon cancer and hypothetic mechanisms of its anti-tumor action.