Title: Gastroenterological symptoms in cystic fibrosis
- Robert Śmigiel, Franciszek Iwańczak
- Review articles
- Polish Gastroenterology
- Start page:
- Final page:
- cystic fibrosis, gastroenterological symptoms, pancreas, liver, meconium ileus
Cystic fibrosis is the most common autosomal recessive genetic defect of one gene coding transmembra-ne protein CFTR. Its incidence in Europe and Poland is estimated as 1:2500 live births. The consequen-ce of defected CFTR gene is the impairment of membrane transport of the chloride ions leading to produc-tion of the condense and viscous secretion in all epithelial cells. It results in a chronic lung and gastrointestinal disorders, congenital bilateral absence of vas deferens and increased level of chloride ions in the sweat. A lot of gastrointestinal diseases and symptoms in cystic fibrosis comprise each part of digestive tract. The most common diseases and clinical manifestations of the gastrointestinal tract in cystic fibrosis, its patho-mechanism, main rules in diagnosis and treatment are described in this article.