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Articles

Title: Influence of omeprazole on pain relief and remission of gastritis in children

Author:
Iwona Ignyś, Beata Klincewicz, Wojciech Cichy
Type:
Original articles
Language:
EN
Journal:
Polish Gastroenterology
Year:
2003
Volume:
10
Number:
5
Start page:
407
Final page:
412
ISSN:
1232-9886
Keywords:
children, omeprazole, treatment, pain, gastritis
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Introduction: Both gastritis and peptic ulcers are multifactorial processes resulting from the balance disturban-ces between aggressive factors and the protective ones. Despite immense diagnostic and therapeutic pro-gress, the evaluation concerning efficacyandsafetyofthe recently introduced PPI drugshas not been car-ried out yet. The aim of the study was to evaluate the influence of treatment with the use of a new drug from the PPI group (Polprazol 10 mg) on the duration and efficacy of abdominal pain relief and the assessment of macrosco-pic and histological changes in children with gastritis. Material and methods: 30 children aged 6-10 were enrolled in the study. The following examinations were per-formed: gastroduodenoscopy with macroscopic assessment of gastric and duodenal mucosa, histological and histochemical examinations, and ureasic test. All children were treated with Polprazol, Amoxicillin, Cla-rithromycin. Six weeks after finishing therapy, control examinations were performed. Intensity of abdominal pain before treatment (D-0), on the fourth day (D-4) and after the 7-day-long triple therapy (D-8), after the PPI treatment (D-22) and on the day of control gastroscopy (D-50) was evaluated on the basis of case history, clinical examination and a visual analogue scale, prepared for the study, which al-lows the child for subjective assessment of his ailments Results: In 11 out of 28 patients abdominal pain subsided after finishing a 7-day-long therapy. In 5 children, the longer use of Polprazol for another 4 weeks brought remission of clinical symptoms. 2 patients compla-ined about abdominal pain all the time. In control examinations we observed macroscopic and clinical remission of inflammatory changes in 20 patients. 7 children did not report for control examinations. Conclusions: Based on the obtained results, Polprazol seems to be an efficient and safe drug in treatment of chronic gastritis and peptic ulcers in children.