Title: Barrett oesophagus and adenocarcinoma of the oesophagus: progress in the diagnosis and treatment at the end of XX century
- Wojciech Polkowski, Grażyna Polkowska, Jerzy Melko
- Review articles
- Polish Gastroenterology
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- Final page:
- Barrett oesophagus, adenocarcinoma of the oesophagus, dysplasia, endoscopic surveillance, anti-reflux therapy
Intestinal-type columnar epithelium in the oesophagus, known as Barrett oesophagus, is well-defined pre-malignant condition. The risk for the development of oesophageal adenocarcinoma in a patient with Barrett oesophagus is at least 30 times higher when compared to the normal population. The development of in-vasive cancer in Barrett oesophagus is preceded by stages of progressively severe dysplastic changes. With current therapeutic options, when clinical manifestation of this cancer occurs, it is too late for cure in the majority of patients. Therefore, attention should be focused on early diagnosis of the malignancy, prefera-bly in its preinvasive phase (dysplasia). An accurate and reproducible diagnosis of dysplasia in Barrett oesophagus might ultimately lead to targeted therapeutic interventions or cancer prevention in the future. This review is focused on recent progress in the diagnosis, management, and intervention in patients with Barrett oesophagus or adenocarcinoma of the oesophagus.