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Title: Basal concentration of substance P and vasoactive intestinal peptide in the blood serum of children with gastritis and duodenitis

Urszula Grzybowska-Chlebowczyk, Halina Woś, Sabina Więcek, Maciej Kajor, Renata Dec
Original articles
Polish Gastroenterology
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substance P, vasoactive intestinal peptide, gastritis, duodenitis

Neurohormones are widespread in the gastrointestinal tract, where they play an important role in motority, secretion and immunological and inflammatory responses. A number of cytokinins and mediators, synthe-sis and stimulation of which are controlled by neuromediators, for example substance P and vasoactive intestinal peptide, are connected with inflammatory processes of gastric mucosa. Aim of l and methods: We determined by radioimmunological method, using KIT byAB Sweden firm, basal concentration of SP and VIP in blood serum of 13 children aged between 5-12 years, in which we diagnosed gastritis and/or duodenitis based on macro and microscopic picture examination. 7 healthy children in the similar age madę a control group. Endoscopy of upper part of alimentary tract, histopathological examina-tion of biopsy specimen from visibly changed places, examination in the direction of Helicobacterpylori in-fection (CLO-test) and examination in direction of food allergy were performed in all patients during the dia-gnostic process. Moreover, in children with deficiency of body mass biopsy specimen were taken from small intestine mucosa in order to diagnose malabsorption syndrome. Additionaly on the ground of immunologi-cal examinations we excluded coeliac disease. Results: The values of both neurohormones differed in dependence on the location of inflammatory changes. The mean values of SP in children with gastritis were higher and in children with duodenitis Iower in com-parison to values of SP in the control group, but we did not find statistical significance. We found converse significance in analysis of VIP concentration - the mean values were Iower in children with gastritis and they were higher in children with duodenitis in comparison to the control group, but we did not find any statistical significance, either. Onlyvaluesoftotal IgE were statistically significantly higher in children with gastritis in comparison to the control group. Conclusions: It seems that neuropeptides such as SP or VIP play an important role in transmission of stimuli in immunoendocrinal system determining the basisof homeostasisoftheorganism. All disturbanceswhich take place in this system may have influence on the values of neurohormones.