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Title: Factors affecting improvement of biochemical liver function tests in alcohol dependent males after four weeks abstinence period

Jacek Budzyński, Marcin Ziółkowski, Maria Kłopocka, Janusz Rybakowski, Maciej Świątkowski, Wojciech Kosmowski
Original articles
Polish Gastroenterology
Start page:
Final page:
alcoholic liver disease, alcohol dependence, alcohol abstinence, liver function tests

Background: The effect of clinical factors on the improvement in liver function tests during alcohol abstinence period is still not clear. The aim of the study was to determine factors affecting the changes in liver function tests values after four weeks of alcohol abstinence period. Material and methods: 160 alcohol-dependent male patients (according to ICD-10) were studied. In all patients at the beginning of the study and after 4 weeks of controlled abstinence the estimation of bilirubin and pla-sma protein fractions as well as y-glutamyltranspeptidase (GTP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities was made. Results: After 4 weeks of abstinence a significant decrease of bilirubin, GTP, AST, ALT and DeRitis index va-lues was found. The values of liver function tests at the study beginning and their changes after 4 weeks of abstinence had relation to the duration of abstinence period, thyreotropin (TSH) concentration at the study beginning, thefrequency of alcohol consumption during 90days before the study, family history of alcoho-lism, age of alcohol dependence onset, time of alcohol dependence duration and its severity estimated on the basis of the presence of withdrawal epilepsy and delirium tremens in anamnesis, decrease in alcohol tolerance, "non-consumptive" alcohol beverages drinking, as well as the results of Short Alcohol Depen-dence Data (SADD) scale and Polish version of Michigan Alcoholism Screening Test (MAST). Higher TSH level had a protective effect on bilirubin concentration, but negative effect on changes in liver enzymes ac-tivities. No significant influence of quantity of alcohol drinking during 90 days before the study start on the levels of studied liver function tests was found. Conclusion: The main factors affecting improvement in biochemical liver function tests were: time of abstinen-ce duration, pituitary-thyroid axis function and some markers of alcohol dependence severity.