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Articles

Title: Selective immunoglobulin A deficiency

Author:
Alicja Binek, Przemysława Jarosz-Chobot
Type:
Review articles
Language:
PL
Journal:
Pediatric Endocrinology, Diabetes and Metabolism
Year:
2012
Volume:
18
Number:
2
Start page:
76
Final page:
78
ISSN:
2081-237X
Keywords:
immunoglobulin A, IgA deficiency, autoimmunity
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Immunoglobulin class A is the main protein of the mucosal immune system. Selective immunoglobulin A deficiency (sIgAD) is the most common primary immunodeficiency in Caucasians. sIGAD is strongly associated with the certain major histocompatibility complex region. Most individuals with sIgAD are asymptomatic and identified coincidentally. However, some patients may present with recurrent infections, allergic disordes and autoimmune manifestations. Several autoimmune diseases, such as systemic lupus erythematosus, diabetes mellitus type 1, Graves disease and celiac disease, are associated with an increased prevalence of sIgAD. Screening for sIgAD in coeliac disease is essential. Patients need treatment of associated diseases. It is also known that IgA deficiency may progress into a common variable immunodeficiency (CVID). Pathogenesis and molecular mechanism involved in sIgAD should be elucidated in the future.