Title: Urolithiasis risk factors in obese and overweight children
- Hanna Borysewicz-Sańczyk, Tadeusz Porowski, Andrzej Hryniewicz, Marcin Baran, Aneta Zasim, Artur Bossowski
- Original articles
- Pediatric Endocrinology, Diabetes and Metabolism
- Start page:
- Final page:
- pediatrics, urolithiasis, obesity
Introduction: Childhood obesity is becoming a worldwide epidemic and its metabolic and cardiovascular complications
may already be evident at a young age. Several epidemiologic studies in adults have clearly demonstrated
that obesity and overweight increase the risk of kidney disease and urolithiasis.
Aim of the study: The purpose of this study was to evaluate the relationship between overweight and obesity
and urolithiasis risk factors in children.
Materials and methods: The main kidney stones risk factors in urine such as calcium concentration, oxalate
concentration, citrate concentration, pH of urine as well as BRI (Bonn Risk Index) were analyzed in 249 overweight
and obese children (study group) and in 281 children with normal weight (control) at the age of 3 to 18 years old.
Results: In the study group the mean oxalate concentration was significantly higher than in the control (0.52±0.48
vs. 0.26±0.12; p <0.05). The mean calcium concentration of overweight/obese patients was higher than that of
normal body weight and the difference was close to statistically significant (3.23±2.55 vs 2.58±1.59; p=0.0537). The
mean urine pH in the study group was 6.28±0.46 and was significantly lower (p <0.05) than the mean urine pH in
the control, witch was 6.40±0.47. The mean citrate concentration among overweight/obese patients was significantly
lower than in control (431,2±309,5 vs. 637,2±310,7; p <0.05).
Conclusions: Our results suggest that obesity or overweight at a young age are associated with an increased risk
of kidney stones. Weight loss might be explored as a potential treatment to prevent kidney stone formation.