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Articles

Title: Utility of positron emission tomography (PET) and combined positron emission tomography and computed tomography (PET/CT) in patients with gastric cancer

Author:
Zbigniew Kula
Type:
Review articles
Language:
PL
Journal:
Polish Gastroenterology
Year:
2010
Volume:
17
Number:
4
Start page:
286
Final page:
290
ISSN:
1232-9886
Keywords:
positron emission tomography, computed tomography, gastric cancer
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The application of positron emission tomography (PET) by using 18F-fluorodeoxyglucose (FDG) constitutes the latest method of functional imaging. In oncological diagnostic the method is based on the enlarged uptake of positron radiotracer by cancer cells. Combined FDG-PET scanning and computed tomography (CT) offer wider diagnostic possibilities. FDG-PET and FDG-PET/CT have been reported to provide an increased accuracy in the diagnosis of primary and recurrent colorectal and esophageal cancer, but in cases of stomach neoplasms they can be applied only to a limited extent. However FDG-PET and FDG-PET/CT image in selected patients with gastric cancer varied in preoperative staging of primary tumor, and it may change the clinical management by detecting additional distal lesions. FDG-PET/CT is useful for a recurrent disease detection in patients with high suspicion of recurrence based on conventional methods. FDG-PET/CT may improve early evaluation of response to treatment and the prognosis in patients with gastric cancer. An alternative radiotracer 18F-fluorothymidine (FLT) provides better sensitivity and specificity for the method. Further studies are needed to evaluate the clinical usefulness of FDG- and FLT-PET/CT for preoperative staging of gastric cancer, detection of distant metastases and recurrence, as well as for the monitoring of tumor response to treatment.