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Articles

Title: Disturbances of the thyroid function in patients with anorexia nervosa

Author:
Alicja Smorawińska, Eugeniusz Korman, Andrzej Rajewski
Type:
Original articles
Language:
PL
Journal:
Pediatric Endocrinology, Diabetes and Metabolism
Year:
2001
Volume:
7
Number:
2
Start page:
81
Final page:
84
ISSN:
2081-237X
Keywords:
anorexia nervosa, thyroid function, reverse T3, TSH response to TRH
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There are clinical similarities between anorexia nervosa (AN) and hypothyroidism. Previous reports have shown reverse fT3, ­rT3, sporadically reverse fT4 and normal levels of serum TSH. To asses thyroid function in 36 patients with AN (4 boys, 32 girls, the subjects ages ranged from 12 to 18 years) serum levels of fT4, fT3, rT3, TSH were measured. We examined activation of the hypthalamic - pituitary- thyroid axis by useing TRH test (TRH i.v. 0,2 mg, measured TSH at 0', 30', 60', 90') in 30 patients out of this group. 67% (24) patients of the examined group resulted in low level of fT4 (0,75-0,97 ng/dcl), but low reverse fT3 (=0,67 pg/ml) was only found with 1. The level of rT3 were normal. The level of TSH were low (0,87-0,97 µIU/ml) in 25% (9) of patients, but 6 of them also manifested low reverse fT4 (0,87-0,97 ng/dcl). A hyporesponse of TSH to TRH was noted in 17% (5) of patients, a delayed TSH response to TRH was seen only in 1. Thyroidal dysfunction in AN was basically expressed by low reverse fT4, and also by the disturbances of the TRH-TSH secretion.