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Articles

Title: Evaluation of serotonin and melatonin metabolism indices in patients with ulcerative colitis

Author:
Maria Wiśniewska-Jarosińska, Patrycja Boznańska-Świętaszek, Marzena Mokwińska, Agnieszka Stępień, Jan Chojnacki
Type:
Original articles
Language:
EN
Journal:
Polish Gastroenterology
Year:
2009
Volume:
16
Number:
5
Start page:
358
Final page:
362
ISSN:
1232-9886
Keywords:
ulcerative colitis. serotonin, melatonin, 5-hydroxyindole acetic acid (5-HIAA), 6-hydroxymelatonin sulfate (6-HMS)
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Introduction: Ulcerative colitis (UC) is a chronic inflammatory disease in which immunological factors play a crucial role. Serotonin and melatonin are mainly produced within the gastrointestinal tract in a common metabolic pathway and they affect both inflammatory and immunological processes. The main metabolite of serotonin is 5-hydroxyindole acetic acid (5-HIAA) and of melatonin - hydroxymelatonin sulfate (6-HMS). It has been suggested that the amounts of these metabolites excreted in urine are proportional to their body pool. Aim of the study: The study aimed to evaluate whether the amounts of 5-HIAA and 6-HMS excreted in the urine of patients with UC change and if the changes depend on the clinical state. Material and methods: The study comprised 75 persons aged 20-47 years (mean age 33.4 years), of whom 25 were clinically healthy, 25 had mild exacerbation, and 25 had severe exacerbation of UC according to Truloves and Witts? classification. 5-HIAA and 6-HMS concentrations in urine were measured by ELISA applying IBL antibodies (RE-59131 and RE-54031). Results: 5-HIAA urinary excretion was 5.77?2.33 mg/24-h in the healthy controls, 5.75?2.81 mg/24-h in the patients with mild exacerbation (p>0.05), and 2.60?2.28 mg/24-h (p<0.01) in those with severe exacerbation of UC. 6-HMS urinary excretion in the healthy controls was 15.34?7.27 ?g/24-h and in the patients with mild and severe UC it was 32.82?17.17 ?g/24-h (p<0.01) and 22.71?10.22 ?g/24-h (p<0.05), respectively. Positive correlation between 5-HIAA and 6-HMS urinary excretion was found only for the healthy controls (r=0.7268, p<0.01). Such correlation was not observed for the patients with mild or severe exacerbation of UC (r=0.2815, r=0.2688, p>0.05). Conclusions: 1. The homeostasis of serotonin and melatonin is disturbed in patients with UC and the degree of change correlates with the severity of disease exacerbation. 2. Evaluation of 5-HIAA and 6-HMS 24-hour urinary excretion can be useful in choosing a rational therapy for UC.