Title: Oxygen metabolism in systemic lupus erythematosus
- Elżbieta Waszczykowska, Jolanta Dorota Torzecka, Ewa Robak, Bożena Dziankowska-Bartkowiak, Anna Sysa-Jędrzejowska
- type 5
- Clinical Dermatology
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- SLE, free radicals, SOD-1, GSH-Px, MDA
Introduction and aim of study: As it is indicated by the results of some studies, free radicals take part in the process of cell damage, especially in chronic inflammatory processes such as SLE.] Material and methods: The study was performed in the group of 63 patients at different stages of systemic lupus erythematosus (SLE) activity. Superoxide radical (O2?- ) generation by granulocytes was assessed by Bellavite et al. method, superoxide dismutase (SOD-1) by Misra and Fridovich method, catalase by Beers and Sizer method, peroxidase (GSH-Px) activity by Little and O?Brien method and malonyl dialdehyde (MDA) concentration by Placer et al. Results and conclusions: We observed positive correlation between O2?- generation, MDA concentration and disease activity as well as negative between SOD-1, catalase GSH-Px activity and disease activity. These data suggest involvement of free radicals as one of the factors taking part in SLE pathogenesis.