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Articles

Title: Application of copper-binding peptides in the cosmetic dermatology.

Author:
Arkadiusz Gruchlik, Ewa Chodurek, Maja Nowak, Zofia Dzierżewicz
Type:
Review articles
Language:
PL
Journal:
Clinical Dermatology
Year:
2009
Volume:
11
Number:
3
Start page:
175
Final page:
178
ISSN:
1730-7201
Keywords:
glycyl-histidyl-lysine (GHK), copper, ion transport, biological availability, skin aging
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Wrinkles in the skin are caused by degenerative changes in the proteins of the dermal extracellular matrix and by reactive oxygen particles generation in skin cells. Stimulation of neosynthesis of these proteins in the dermis may result in improvement of wrinkles. Fibroblasts are responsible for new collagen and other protein synthesis in the dermis. There are many anti-wrinkle products, for example tretinoin or retinol which improve fine wrinkles by increasing collagen production, but these compounds have irritating properties. Recently much attention has been focuced on the peptides and copper peptide complexes, which have a good skin tolerance. These peptides were first described as growth factors for a variety of differentiated cells but recent data suggested a physiological role related to the process of wound healing and tissue repair. Peptides, such as Gly-His-Lys (GHK) may be used to stabilize and deliver copper into cells. As a cosmeceutical, copper peptides could improve skin firmness, fine wrinkles, and hyperpigmentation. It participates in collagen and elastin formation, downregulates matrix metalloproteinases, and reduces the activity of collagenase. Copper is a required cofactor for the enzyme superoxide dismutase (SOD), therefore it has an antioxidant properties.