Title: Apoptosis stimulating and inhibiting factors in the gastric mucosa of children with Helicobacter pylori
- Elżbieta Maciorkowska, Ewa Ryszczuk, Maciej Kaczmarski
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- apoptosis, Helicobacter pylori, children
Apoptosis isa processof physiologically programmed cell death, inevitable for intracellular homeostasis. In Helicobacter pylori (H. pylori) infection, the rate of apoptotic cells occurrence increases from 3 to 16%. Virulence factors - VacA, CagA, lipopolysaccharide (LPS), monocyte-activating peptide, ammonia, urease, and pro-inflammatory cytokine are factors stimulating apoptosis in H. pylori infection. On the other hand, there are 2 basic pathogenetic pathways, by which apoptosis occurs in the host mucosa, i.e. the external pathoge-netic or receptor pathway, which takes place with the participation of such receptors as CD95, epidermal factor growth receptor (EGFR), and the internal pathway, that occurs with mitochondrial proteins of bcl-2 family.
Apoptotic mechanisms should betaken into consideration in pediatric patients with H. pylori as apoptosis in gastric mucositiscan have importantclinical implications.
The research results imply the possibility of apoptosis participation in the pathogenesis of gastric ulceration while in case of long-term H. pylori infection, intensified apoptosis, which is not balanced by increased proliferation, can lead to gastric mucosa atrophy.