Title: The role of lymphocytes and secrete cytokines in autoimmune thyroid diseases
- Ewa Polkowska, Artur Bossowski
- Review articles
- Pediatric Endocrinology, Diabetes and Metabolism
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- regulatoryT cells, cytokines, autoimmune thyroid diseases
Grave's disease and autoimmune hypothyroidism represent the two main autoimmune thyroid diseases, where an immune response is directed against the thyroid gland. The essenceofthese diseases islossoftoleranceofowntissuescaused by malfunctionoftheT lymphocytes, whicheffecttheproduction of antibodies reacting with particular cell structures and tissues. Cytokines participate in the induction and effector phase of the immune and inflamma-tory response and therefore play a critical role in the development of autoimmune thyroid diseases. Regulatory T cells take part in regulation of immune response and play a leading role in developing immune tolerance through active suppression.