Title: Roles of PPARs in the origin of metabolic disturbances in children with low birth weight (below 2500 g)
- Ewa Barg
- Review articles
- Pediatric Endocrinology, Diabetes and Metabolism
- Start page:
- Final page:
- PPAR, low birth weight, lipid metabolism, glucose metabolism
Children, who are born with low birth weight (less than 2500 g) are known to have an increased risk of developing metabolic syndrome in later live. PPAR could play a regulatory role in the pathogenesis of hyperlipidemia disturbance and a modulatory role in the control of inflammatory response. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand -dependent transcription factors with pleiotropic effects on lipid metabolism, glucose homeostasis, cell proliferation, control of inflammation and atherosclerosis. Three isoforms of PPAR, i.e. a, p, y havebeen identified and are differentially expressed in various tissues and play different metabolic functions. In this review, the roles of PPAR and their implicationsin the control ofvascular inflammation and atherosclerosis are discussed, especially in the groupof risk developing metabolic syndrome -children with low birth weight (below 2500 g).