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Articles

Title: Assessment of antifungal activity of new synthetised benzimidazole compounds

Author:
Cecylia R. Łukaszuk, Elżbieta Krajewska-Kułak, Andrzej Niewiadomy, Joanna Stachowicz, Urszula Głaszcz
Type:
Original articles
Language:
PL
Journal:
Medical Mycology
Year:
2009
Volume:
16
Number:
1
Start page:
24
Final page:
28
ISSN:
1232-986X
Keywords:
benzimidazoles, Candida albicans, non-Candida albicans
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Purpose:The aim of the study was the determination of antifungal activity of new of benzimidazoles against Candida albicans and non-Candida albicans strains. Material and methods:The determination of antifungal activity of benzimidazoles against 38 of Candidaalbicans and 18 non-Candida albicans strains was performed. Benzimidazoles were synthesized in the Department of Chemistry University of Agriculture in Lublin. Results:The mean MIC of benzimidazoles against Candidaalbicans strains was 138.39±37.5 mg/l (65.6-200 mg/l) on Sabouraud's medium.The mean MIC of benzimidazoles against non- Candidaalbicans strains was1 34.12±33.25 mg/l (50-200 mg/l). Conclusion: It seems that benzimidazoles exert potent antifungal activity against the yeast-likefungi strains in vitro.