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Articles

Title: Characteristics of fungi present in the intensive care unit environment. Part 2. Cytotoxicity of the isolated Aspergillus fungi

Author:
Agnieszka Gniadek, Anna B. Macura, Magdalena Twarużek
Type:
Original articles
Language:
PL
Journal:
Medical Mycology
Year:
2009
Volume:
16
Number:
1
Start page:
15
Final page:
18
ISSN:
1232-986X
Keywords:
environment, cytotoxicity,Aspergillus
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Introduction: It is essential in the medical care for immunocompromised patients that the environment should create minimal infection risk. Particularly, it concerns fungal infections. Objective: The objective of the study was evaluation of the cytotoxicity of fungal strains Aspergillus present in the environment of an air conditioned intensive care unit at an infectious diseases clinic. Material and methods: Out of the fungi isolated from the environment in eleven rooms at the Intensive Care Unit in the Gastroenterology, Hepatology and Infectious Diseases Clinic in the University Hospital CM UJ in Kraków, 9 Aspergillus strains were chosen to detailed evaluation of their cytotoxicity using a 3-(4,5-dimethylthiazol--2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. Results:The mouldsAspergillus were present in all of the rooms tested. Out of the nine strains tested using MTT, eight ones turned out to be cytotoxic. Conclusions: Cytotoxic Aspergillus strains present in the environment of immunocompromised patients may be potentially dangerous to them.