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Articles

Title: The bioequivalence of proton pump inhibitors

Author:
Katarzyna Neubauer, Adam Smereka, Ewa Chlebda, Adam Szeląg, Leszek Paradowski
Type:
Review articles
Language:
PL
Journal:
Polish Gastroenterology
Year:
2008
Volume:
15
Number:
4
Start page:
245
Final page:
250
ISSN:
1232-9886
Keywords:
proton pump inhibitors, bioequivalence
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Proton pump inhibitors (PPI): omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole have the same mechanism of action; however different pharmacokinetic and pharmacodynamic properties. Clinical importance of those differences is not totally elucidated. An action of PPI is also impacted by isoenzyme CYP2C19 polymorphism. The dose equivalency of the PPI is an additional problem.