Title: Anti-inflammatory and antithrombotic efects of fibrates
- Anetta Undas
- Review articles
- Polish Journal of Cardiology
- Start page:
- Final page:
- fibrates, inflammation, blood coagulation, tissue factor, fibrinolysis
Beyond hypolipemic effects, fibrates that are synthetic agonists of the nuclear peroxisome proliferator-activated receptors alpha (PPARa), produce additional actions of potential benefit such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, stimulation of fibrinolysis, modulation of angiogenesis, attenuation of oxidativestress. Among socalled pleiotropic effects of fibrates that may limit the development of atherosclerosis and its complications, anti-inflammatory and antithrombotic properties play a major role. Fibrate treatment has been reported to decrease plasma levels of C-reactive protein (by 20 to 50%), interleukin 6, and interleukin l|3.This class of drugs cande-crease plasma fibrinogen levels, on average, by 10% through the down-regulation of the expression of the fibrinogen genes. Anticoagulant actions of fibrates, reflected by reduced thrombin formation following vascular injury, result likely from the down-regulation of tissue factor (TF) expression. Recently, impaired platelet activation has been shown in dyslipidemic patients in whom the fibrate induced the greatest reduction in trigly-cerides and increase in HDL cholesterol. Clinical relevance of anti-inflammatory and antithrombotic effects of fibrate administration remains to beestablished.