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Articles

Title: Comparison of certain itraconazole forms based on given physicochemical and pharmacokinetic data

Author:
Jan Kuryszko, Krzysztof Marycz, Aleksander A. Kubis, Eugeniusz Baran
Type:
Original articles
Language:
PL
Journal:
Medical Mycology
Year:
2007
Volume:
14
Number:
1
Start page:
15
Final page:
17
ISSN:
1232-986X
Keywords:
itraconazole, Orungal, Trioxal, drug's blood level
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Introduction: Original and generic substances are becaming subject of pharmacological analyses. Aim: Pharmacokinetical differentiation between Orungal and Trioxal parameters led up to analysis of influencing factors. Material and methods: Orungal micropellets and Trioxal granules were used in the study. Electronic microscope pictures were analysed and solution time according to FP VI measured. In addition, data included in the description of both compounds were analysed. Results: Pharmacokinetic features of bouth compounds correlated with ultrastructure and solution times of pelletes and granules. Conclusions: Itraconazole blood level dependson applied drug form.