Title: Comparison of certain itraconazole forms based on given physicochemical and pharmacokinetic data
- Jan Kuryszko, Krzysztof Marycz, Aleksander A. Kubis, Eugeniusz Baran
- Original articles
- Medical Mycology
- Start page:
- Final page:
- itraconazole, Orungal, Trioxal, drug's blood level
Introduction: Original and generic substances are becaming subject of pharmacological analyses.
Aim: Pharmacokinetical differentiation between Orungal and Trioxal parameters led up to analysis of influencing factors.
Material and methods: Orungal micropellets and Trioxal granules were used in the study. Electronic microscope pictures were analysed and solution time according to FP VI measured. In addition, data included in the description of both compounds were analysed.
Results: Pharmacokinetic features of bouth compounds correlated with ultrastructure and solution times of pelletes and granules.
Conclusions: Itraconazole blood level dependson applied drug form.