Title: Thalassemia - pathogenesis, diagnostics, therapy
- Barbara Tejza, Andrzej Kurylak, Monika Pogorzała, Anna Krenska
- Pediatric Review
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- anaemia, thalassemia, children
Thalassemia is an inborn, genetically conditioned anaemia which belongs to the group of quantitative haemoglobinopathies. This condition is caused by a disorder in the (a or P) globin chain synthesis. This abnormal haemoglobin is found in reduced quantities and differs qualitatively. This influences the delivery of oxygen to tissues and conditions haemolitic character of anaemia. It is classified in the group of microcytic anaemias because of a small hypochromic erythrocyte and is haematologically similar to si-deropenic anaemia. We would like to pay attention to the problem of thalassemia in our geographical region and to emphasise the necessity for taking into account this disorder in the differential diagnostics.