Title: Cyclopirox olamine - mechnism of action and efficacy - new opinions
- Ewa Plomer-Niezgoda, Joanna Maj, Anita Hryncewicz-Gwóźdź, Anna Czarnecka
- Review articles
- Medical Mycology
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- cyklopirox, efficacy, mechanism of action
Ciclopiroxolamine is effective topical antifungal drugs with activity against a broad spectrum of dermatophytes yeasts, moulds, dimorphic fungi and Gram-positive and Gram-negative bacteria. Ciclopirox may also act throught chelatation with poliwalent metal kations as Fe3+ and Al3+ and has an inhibitory effect on enzymes that are involved in the cellular processes of fungi. Ciclopirox olamine have anti-inflammatory activity, inhibits prostaglandin and leukotriene synthesis. Open and controlled trials in patients with dermatomycoses and candidiases have revelated that ciclo-pirox olamine is morę effective than placebo and at least as effective as imidazoles. Side effects occurred in 1-4% of patients. The most common side effects included burning sensation of the skin, irritation, redness, pain or pruritus. There are very few reports of allergic contact dermatitis.