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Articles

Title: Cyclopirox olamine - mechnism of action and efficacy - new opinions

Author:
Ewa Plomer-Niezgoda, Joanna Maj, Anita Hryncewicz-Gwóźdź, Anna Czarnecka
Type:
Review articles
Language:
PL
Journal:
Medical Mycology
Year:
2006
Volume:
13
Number:
2
Start page:
149
Final page:
152
ISSN:
1232-986X
Keywords:
cyklopirox, efficacy, mechanism of action
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Ciclopiroxolamine is effective topical antifungal drugs with activity against a broad spectrum of dermatophytes yeasts, moulds, dimorphic fungi and Gram-positive and Gram-negative bacteria. Ciclopirox may also act throught chelatation with poliwalent metal kations as Fe3+ and Al3+ and has an inhibitory effect on enzymes that are involved in the cellular processes of fungi. Ciclopirox olamine have anti-inflammatory activity, inhibits prostaglandin and leukotriene synthesis. Open and controlled trials in patients with dermatomycoses and candidiases have revelated that ciclo-pirox olamine is morę effective than placebo and at least as effective as imidazoles. Side effects occurred in 1-4% of patients. The most common side effects included burning sensation of the skin, irritation, redness, pain or pruritus. There are very few reports of allergic contact dermatitis.