Title: Incidence of antibiotic associated diarrhoea in children
- Maria Kotowska, Piotr Albrecht, Jan Józefczuk, Małgorzata Armańska, Grażyna Ostapińska-Karaś, Magdalena Kochańska, Hanna Szajewska
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- antibiotic associated diarrhoea, antibiotics, Clostriclium clifficile
Introduction: Antibiotic associated diarrhoea (AAD) is the most common side effect of antibiotic therapy. The incidence of AAD varies from 5 to 39%. The incidence of AAD among paediatric population in Poland remains unclear.
Objectives: To evaluate the incidence of antibiotic associated diarrhoea in children treated with antibiotics for acute respiratory tract infection and(or) otitis media.
Material and methods: Eligible patients were those aged 6 months to 14 years with acute otitis media and(or) respiratory tract infection who started short-treatment with orał or intravenous antibiotics within 24 h of enrolment. The primary outcome measure was AAD defined as >3 loose or watery stools per day for a minimum of 48 hours, occurring during and/or up to 2 weeks aftertheend of the antibiotic therapy, caused by C clifficile or for otherwise unexplained diarrhea (i.e., negative stool culture).
Results: Of the 137 patients, 127 completed the study. AAD was diagnosed in 22/127 (17.3%) children. The incidence of AAD was signifi-cantly higher in children treated with amoxicillin compared with other antibiotics [7/20 (35%) vs 15/107 (14%); relative risk 2.5 (95% confidence interval, Cl 1-5]. The setting (hospital/outpatient) or route of administration (orally/intravenously) did not influence the incidence of AAD. There was no need for discontinuation of antibiotic treatment. No child need hospital treatment because of diarrhoea or intrave-nous rehydration.
Conclusions: The study demonstrates high incidence of antibiotic-associated diarrhoea in children treated with antibiotics for otitis media and(or) respiratory tract infections, particularly in those treated with amoxicilline.