Title: The erwironmental health riskof children exposed to persistent organie pollutants
- Jolanta Tracz
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- persistent organie pollutants (POPs), breast feeding, developmental disorders, epidemiology
POPs (persistent organie pollutants), also know as "endocrine disruptors" or "xenohormones" are the most toxic group of environmental pollutants consisting of some pesticides, polychlorinated biphenyls (PCBs) and dioxin. Pesticides and polychlorinated biphenyls have been produced commercially for some five decades. Dioxins are mainly by-products of industrial combustion processes including medical waste incineration. Food products, especially dairy, meat, and fish are the primary source of environmental exposure to POPs in the generał population. POPs produce a variety of toxic and biochemical changes, some of which oceur at very Iow doses and last for long periods of time.
POPs modulate the levels of many hormonal systems by mimicing, blocking, or modulating the endogenous Chemical messengers. The complex alternation of multiple endocrine systems is likely associated with the speetrum of adverse developmental effects. Exposure to POPs oceurs both in utero and through breastfeeding. This article presents the sources of exposure to POPs, toxicological characteristic of POPs, physiologic and metabolic factors that vulnerable children risk from environmental toxins. Also the adverse effects of POPs on the central nervous, immune, reproductive and endocrine system are presented