Title: Clinical remission in type 1 diabetes mellitus
- Marcin Krokowski, Agnieszka Zmysłowska, Jerzy Bodalski
- Review articles
- Pediatric Endocrinology, Diabetes and Metabolism
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- Final page:
- type 1 diabetes, clinical remission, insulin treatment, immunointervention
Type 1 diabetes mellitus is caused by autoimmune destruction of b cells of the Langerhans islets. At the earlystage of the disease in some patients clinical remission is observed. Until now no unequivocal criteria of complete or partial remission in diabetes have been established. In order to better define this phenomenon, individual, metabolic and genetic factors as well as immunological markers, which can influence therate and length of remission, should be considered in greater detail. The state of remission is, however, transitoryand all attempts to extend it result in immunosupressive therapy. The latest investigations also point tothe influence of the insulin treatment on the prevalence and duration of the clinical remission in type 1 diabetesmellitus. These studies seem to be fully justified, taking into consideration the mechanisms of interferenceof exogenous insulin in the immunological process.