Title: The evaluation of the selected parameters of the immunological responses in children with gastroduodenitis chronica and concomitant Helicobacter pylori infections - preliminary study
- Anna Krenska-Wiącek, Mieczysława Czerwionka-Szaflarska, Mariusz Wysocki, Magdalena Żbikowska-Gotz
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- gastritis et duodenitis chronica, Helicobacter pylori, immunological estimate, children
H.p. infeetion belongs to the major etiological agents of the chronić gastritis and duodenitis. The course of the infeetion depends both on strain virulence and host immune system. In some conditions abnormal immune response may not lead to the H.p. eradication and even exacerbate inflammation. The predominance of the cell-mediated immune response, with the main role of T lymphocyte oceurs in H.p. infections. With respect to the cytokine profile there are two types of Th lymphocytes: Th1 lymphocytes producing inflam-matory cytokines as IFN-y, TNF-a and Th2 lymphocytes producing antiinflammatory cytokines as Il—4, Il-10. The aim of the study was the evaluation of the selected immunological parameters in children with chronić gastritis and duodenitis with and without H.p.-infection. 42 children were studied with chronić gastritis and duodenitis and H.p. infections (group I) and 28 children not infected with H.p. (group II). By using flow cytometry method estimations of lymphocytes: B (CD19+), Th (CD4+), Te (CD8+) and NK-cells (CD56+) were madę. The serum cytokine Il—4, Il-10 and IFN-y levels by ELISA method were performed. We found the higher CD4:CD8 lymphocytes index in group I as compared to the group II. In all children both with H.p. infections and without them there were decreases in NKcell proportions. Serum cytokine Il-10 levels were lower and IFN-y higher in group I as compared to the group II. The differences were not statistically significant.