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Articles

Title: Serum and stool interleukin 6 in active and inactive ulcerative colitis in children

Author:
Andrzej Wędrychowicz, Janina Stopyrowa, Krzysztof Fyderek, Witold Mieżyński
Language:
PL
Journal:
Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
Year:
2000
Volume:
2
Number:
3
Start page:
165
Final page:
169
ISSN:
1507-5532
Keywords:
interleukin 6, ulcerative, colitis, children
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Introduction: The data available in the literaturę suggest the role of interleukin 6 (IL-6) in development of ulcerative colitis (UC). It is known thatthere are increased concentrations of this interleukin in serum and colonic mucosa in UC patients. Similar dependences were obtained assessing IL-6 in the gut lavage fluids. The stool IL-6 concentrations levels in active and inactive UC in children still are unclear up to now. Aim: The aim of the present study was to estimate IL-6 concentrations in stool and serum in children with active and inactive UC during the treatment and to evaluate correlation of stool and serum IL-6 concentrations with the activity of UC. Material: There were 38 children with UC, of mean age 2-18 yr, recruited into the study. There were 20 children with active and 18 with inactive UC. The control group consisted of 14 healthy children. Methods: The IL-6 concentrations were measured in the serum and the stool supernatants, using commercial mission to the hospital and after 4 and 12 weeks of the treatment in the active UC children and three times every 4 months in the inactive UC children. The Truelove-Witts clinical activity index was calculated. The endoscopic and histopathologic findings were graded by Roth's endoscopic scalę and standard histopa-thologic scalę. Results: The stool IL-6 concentrations reached higher values than the serum ones both in active and inactive UC children and active UC children values were higher than inactive ones. The stool and the serum IL-6 concentrations decreased gradually in the active UC children during the treatment and were unchanged in the inactive UC children during entire period of the study. The serum IL-6 concentrations correlated sta-tistically significant with endoscopic and histopathologic UC activity (R=0.40; p<0.05) and (R=0.37; p<0.05) respectively but didn't correlate with Truelove-Witts clinical activity index. Stool IL-6 concentrations didn't correlate with Truelove-Witts clinical activity index and endoscopic and histopathołogic UC activity in the active UC children. The stool serum IL-6 i reached lower values in the active UC children than in the controls and in gradually during the treatment but were unchanged in the inactive UC children. Conclusions: Increased serum and stool IL-6 concentrations in the active UC and their correlation with UC activity confirm previous suggestions of IL-6 contribution in development of UC. The serum IL-6 concentrations correlate with intensity of inflammation in the colon. The serum and stool IL-6 concentrations are unchanged in the inactive UC in children.