Title: Fatty liver - problem of future?
- Piotr Socha, Maciej Dądalski, Tomasz Dzik, Jerzy Socha
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- fatty liver, steatohepatitis, lipid peroxydation, EPL
Liver steatosis is a common histological finding in liver biopsy. It can evoke a lot of nonspecific clinical symptoms and abnormalities in biochemical liver tests, but they don't correlate directly to the level of steatosis. There are two types of liver steatosis. The first one, called macrovesicular, is usually benign, and the second one - microvesicular, which is caused by primary or secondary mitochondrial dysfunction, has tendency to change into steatohepatitis. There are some data that this change can be produced by increased lipid peroxydation caused by free radicals. The development of steatohepatitis may lead to liver cirrhosis. The classical example of this process is alcoholic steatohepatitis. The therapy of liver steatosis should consist of elimination of harmful factors, suitable diet and physical activity and pharmacotherapy. Essential phospholipids (EPL) - the main components of the celi membranę, are thought to be basie drug in fatty liver. One considers that intake of antioxidants can stop free radicals cascade. The positive efficacity of complex therapy (EPL+vit. E) in acute hepatitis is evidenced.