Title: Lipids, polyunsaturated fatty cuids and lipid soluble vitamins in obese children
- Tamás Decsi, Dénes Molnár, Berthold Koletzko
- Contemporary Pediatrics, Gastroenterology, Hepatology and Child Feeding
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- a-tocopherol, p-carotene, cholesterol, obese children, polyunsaturated fatty acid
This review discusses the possible significance of the plasma values of the atherogenic lipids, cholesterol and triacylglycerol, the potentially prooxidant polyunsaturated fatty acids and the antioxidant vitamins a-to-copherol and p-carotene in obese children. As far as the atherogenic consequences of being overweight are concerned, one-fourth and morę than one-third of the obese individuals exhibit mild hypercholestero-laemia and hypertriacylglycerolaemia already at teenager ages. Contribution of co-6 long-chain polyunsaturated fatty acids - which are prone to lipid peroxidation - was found to be enhanced in obese as compared to nonobese children in one study. In contrast, availability of the most important lipid soluble antioxidant vi-tamins proved to be markedly reduced in obese subjects as compared to age-matched nonobese controls in several studies. The extent of a-tocopherol deficiency in obese children appears to be related to the degree of fasting hyperinsulinaemia, an indicator of tissue insulin resistance. The findings discussed in this review indicate that disturbances of lipid homeostasis are already present at young age in obese individuals who may benefit from modification of dietary fat and lipid soluble vitamin intakes.