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Articles

Title: Matrix metalloproteinase inhibition - posibility of clinical use

Author:
Krzysztof Kołomecki
Language:
PL
Journal:
Polish Oncology
Year:
2000
Volume:
3
Number:
3
Start page:
163
Final page:
167
ISSN:
1505-6732
Keywords:
angiogenesis, metaloproteinases, inhibitors of metaloproteinases
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Proteolityc enzymes, Zn ion dependent metaloproteases (MMPs), play significant role in the development of neoplasms. They degrade the vascular basal membranę and extracellular ma-trix (ECM) and, therefore, enable tumour growth and formation of distant metastases. The role of MMPs in the development of malignant neoplasms and non-malignant diseases has been confirmed. Natural MMPs inhibitors are: