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Articles

Title: Lewis phenotype and coronary disease

Author:
Tomasz Rechciński, Katarzyna Kołodziej
Type:
Review articles
Language:
PL
Journal:
Polish Journal of Cardiology
Year:
2002
Volume:
4
Number:
4
Start page:
373
Final page:
375
ISSN:
1507-5540
Keywords:
Lewis phenotype, coronary artery disease, reperfusion injury, atherosclerosis
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Lewis blood group oligosaccharides, present on the surface of erythrocytes and many other human cells had recently attracted attention of researchers due to their potential importance in pathogenesis of ische-mic heart disease. The role of these molecules were linked with their participation in leukocytes - endothe-lium adhesion. The results of comparative and epidemiological studies provide evidence that persons with Lewis (a-b-) phenotype have a higher risk of ischemic heart disease. Also the results of some experimental studies on prevention of ischemia - reperfusion tissue injury by pretreatment with Lewis pentasaccharides are reviewed in this article.