Title: Is insulin resistance a risk factor for ischemic heart disease?
- Krzysztof Chiżyński
- Original articles
- Polish Journal of Cardiology
- Start page:
- Final page:
- ischemic heart disease, hyperinsulinism, insulin resistance, diabetes, dyslipidemia
Introduction: Among the well known risk factors of ischemic heart disease (IHD), new potential IHD risk factors are considered such as metabolic syndrome and insulin resistance.
The aim of the study was to analyze the prevalence of insulin resistance in IHD patients. possible association between the insulin resistance and IHD.
Material and methods: There were 590 patients with IHD in study group and 80 patients with normal coronary vessels were as a controls. The analysis of such IHD risk factors as total cholesterol level, HDL and LDL cholesterol, triglycerides, glucose, fibrinogen, PAI-1, smoking, hypertension, diabetes, body mass indexand family history of IHD, myocardial infarction, hypertension and diabetes was performed. The predictor of insulin resistance was calculated in IHD patients and controls. Significance of differences between the frequencies of riskfactors and insulin resistance was calculated by X2 test. Significance of differences were tested using t Studenfs and U Mann-Whitne^s tests. To analyze the influence of insulin resistance and other risk factors on the presence of IHD logistic regression analysis was performed.
Results: In IHD patients there were morę men, and the patients were older than in control group (p=0.013). In the studygroup smoking (p=0.002) and diabetes(p<0.001) wereobserved morę frequently than in controls. The triglycerides levels (p=0.04) and BMI (p=0.007) were higher in the study group. There were no significant difference infibrinogen, PAI-1, total cholesterol, HDL and LDL cholesterol levels, butthepercent of the patients with treated hypercholesterolemia was higher in IHD group than in controls(p<0.001). In this group there were also morę patients with insulinę resistance (p<0.001). Logistic regression analysis (logit) performed taking to attention insulin resistance and other variables, has showed that significant, independent risk factors were: age (p<0.001), treated hypercholesterolemia (p<0.001), smoking (p<0.001), insulin resistance (p=0.011) and diabetes (p=0.029).
Conclusion: Insulin resistance is an independent risk factor for ischemic heart disease in Polish population.