Title: Cell transplants and gene therapy. New methods of teatment of post-infarction circulatory insufficiency
- Natalia Rozwadowska, Dorota Fiszer, Tomasz Siminiak, Ryszard Kalawski, Maciej Kurpisz
- Editorial article
- Polish Journal of Cardiology
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- Final page:
- stem cells, infaretion, gene therapy
The number of cases of post-infarction circulatory insufficiency is still on rise and presently employed forms of therapy do not directly access to the pathologically malformedtissue. The proposed, newtherapeuticat-tempt is based on cellular engineering and gene therapy or combination of both. So far, there have been proposed autologous bonę marrow cells, fibroblasts, myoblasts or kardiomyocytes as the source of tissue transplants to the post-infarction scar. Gene therapy is based upon administration of constructs containing genes connected with angiogenic process: VEGF (vascular endothelial growth factor), bFGF/FGF2 (basie fibroblast growth factor), PDGF-BB (platelet-derived growth factor) and HIF-1 alpha (hypoxia-inducible fac-tor-1 alpha). As well cellular engineering as gene therapy were studied first in animal models. Majority of protocols were successful therefore phase I clinical trials began; at present even phase II clinical trials ha-ve been initiated. Collection of the data will allow to optimize a therapy and perhaps will deliver to patients and physicians a long awaited solution, i.e. successful treatment of inereasing cases of post-infarction circulatory insufficiency. A present review summarizes new methods of treatment of post-infareted heart.