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Articles

Title: Fibrates - why they are important? Statins - why they are more important?

Author:
Jacek Lewandowski, Krzysztof J. Filipiak
Type:
type 5
Language:
PL
Journal:
Polish Journal of Cardiology
Year:
2002
Volume:
4
Number:
3
Start page:
273
Final page:
280
ISSN:
1507-5540
Keywords:
statins, fibrates, dyslipidemias, risk factors
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Fibrates and statins are currently the most widely prescribed hypolipemic drugs. Recently, the therapeutic status of statins seems to increase, although some interesting studies were published regarding fibrates and their role in cardiovasculartherapy. Following the publication of results of HPS (Heart Protection Study), the statins gained more arguments supporting their principal role and possible expansion of clinical indications. The following debate is aimed to compare both groups of drugs as far as their pharmacological properties and evidence-based data from randomized clinical trials are concerned. Two participants of this debate -presenting different views on the subject - comment on the following issues regarding the target drug groups: the epidemiological basis for the position of statins/fibrates in pharmacotherapy, the clinical practice of using statins/fibrates, the evidence-based medical facts for both groups. Each of the debate participants has been also asked to summarize his views on the current therapeutic status of fibrates/statins at the end of discussion.