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Articles

Title: HOPE and Heart Prevention Study (HPS): a new era in preventive cardiology

Author:
Jarosław D. Kasprzak, Maria Krzemińska-Pakuła
Type:
Review articles
Language:
PL
Journal:
Polish Journal of Cardiology
Year:
2002
Volume:
4
Number:
1
Start page:
43
Final page:
47
ISSN:
1507-5540
Keywords:
clinical trials, prevention, sinwastatin, ramipril
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In the era of epidemie atherosclerotic disease one of the most important taks of clinical cardiology is prima-ry and secondary prevention of cardiovascular complications. Two of major completed clinical trials - HOPE and Heart Protection Study HPS - have indicated the possibility of efficient reduetion of cardiovascular risk and improving survival iv extensive groups of patients with cardiovascular risk factors. The results of tre-atment with ramipril and sinwastatin in patients with increased risk of cardiovascular complications are like-lyto expand their indications speetrum and open a new perspective in preventive cardiology. Newongoing trials have to address arising questions regarding the status of statins and converting enzyme inhibitors in prevention - such as optimization of dosage, possible synergistic effects, elucidation of presence or ab-senceof "drug classeffect" and usefulnessof thesedrugsin specific subsets of patients at risk - e.g. tho-se with isolated hypertension.