Title: Doppler echocardiographic evaluation of left ventricular diastolic function in patients with systemie lupus erythematosus
- Ewa Straburzyńska-Migaj, Andrzej Szyszka, Piotr Leszczyński, Kamilla Klama, Andrzej Cieśliński
- Original articles
- Polish Journal of Cardiology
- Start page:
- Final page:
- Doppler echocardiography, left ventricular diastolic function, systemie lupus erythematosus
Introduction: Subclinical myocardial involvement frequently oceurs in patients with systemie lupus erythematosus (SLE).
Aim of the study: The aim of the study was to assess diastolic function of the left ventricle in pts with SLE and no overt heart disease nor epicardial effusion.
Material and methods: 30 pts with SLE (29 women, one man; mean age 39±9 yrs) and 20 age and sex-mat-ched control subjects (19 women, one man; mean age 39±10) underwent M.-mode, 2D and pulsed Doppler echocardiography. LV systolic function was normal. In 7 pts SLE was active. In 17 pts anticardiolipin antibodies were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Compared with the control group, pts with SLE had reduced peak early diastolic flow velocity (peak E)(0.67±0.19 vs. 0.87±0.13m/s; p<0.02), inereased peak late diastolic flow velocity (peak A) (0.66±0.13 vs. 0.59±0.09m/s; p<0.05) and reduced peak Eto peak A ratio (E/A) (1.05±0.27 vs. 1.49±0.24; p<0.05). In addition, the isovolumic relaxation time (IVRT) was significantly prolonged in pts, with SLE (96.3±18.6 vs. 79.5±12.9 ms; p<0.001). Comparing active to non-active SLE pts we found significantly decreased E/A ratio in active pts (0.86±0.19 vs. 1.09±0.29; p<0.02) and significantly prolonged IVRT (108.6±12.1 vs. 92.6±18.8 ms; p<0.02). We did notobserve association of abnormal left ventricular diastolicfilling pat-tern with disease duration, treatment and anticardiolipin antibodies.
Conclusion: Abnormal LV diastolic filling pattern oceurs in pts with SLE with no evidence of overt heart disease, and is morę pronounced in pts with active SLE.